Amnion-derived mesenchymal stromal/stem cell paracrine signals potentiate human liver organoid differentiation: translational implications for liver regeneration

HIGHLIGHTS

  • who: Alessia Gallo and Vitale Miceli from the University of Bari Aldo Moro, Italy have published the article: Amnion-Derived Mesenchymal Stromal/Stem Cell Paracrine Signals Potentiate Human Liver Organoid Differentiation: Translational Implications for Liver Regeneration, in the Journal: (JOURNAL)
  • what: The authors have shown that hAMSCs, principally grown in 3D cultures, are capable of enhancing liver progenitor cell differentiation. This work provides evidence of a direct effect of hAMSCsecreted factors on liver progenitor cell differentiation, revealing a potential approach in liver cell transplantation to improve this process, with the ultimate goal being efficient organ . . .

     

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