HIGHLIGHTS
- who: Roselle Gélinas from the Université University of Sorbonne Paris Cité, Paris, France have published the paper: AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Using low concentrations of AMPK activators, including the direct activator A76966224, the authors show that AMPK activation efficiently inhibits cardiomyocyte hypertrophy without affecting any of the previously-described AMPK downstream targets, suggesting that AMPK regulates cardiac hypertrophy via a not-yet-identified mechanism. The authors report that an increase in protein O-GlcNAcylation is required for cardiac hypertrophy development. More . . .
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