Amtb, a trpm8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the tgfβ signaling pathway

HIGHLIGHTS

• who: Yujie Liu from the In total, female BALB/c nude mice were purchased from Shanghai Slac Laboratory Animal CoLtd. and raised in specific pathogen-free environment until six-week-old. , × , U OS cells were suspended per , μl chilled PBS and subcutaneously injected into the back of each mouse. Mice were then raised and observed on a daily basis until the tumors reached a volume ~, mm3. , mice bearing similar size of tumors were then randomly allocated into four treatment groups: (1) , μl, % glucose + , μl PBS, (2) , μl, % glucose + AMTB (, mg/Kg) resolved in , μl PBS, (3) Cisplatin . . .
  

   

  

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