Amyloid features and neuronal toxicity of mature prion fibrils are highly sensitive to high pressure*

HIGHLIGHTS

• who: Driss El Moustaine from the (UNIVERSITY) have published the research: Amyloid Features and Neuronal Toxicity of Mature Prion Fibrils Are Highly Sensitive to High Pressure*, in the Journal: (JOURNAL) of April/15,/2011
• what: To this aim, the relative contribution of apparent activation enthalpy and entropy to the rate constants was calculated using Equation 2 (see "Experimental Procedures"). The authors show that pressure treatment of amyloid fibrils results in partial structural changes and dissociation concomitantly with a strongly reduced cytotoxicity when compared with initial PrP fibrils.
• how: Similar results were obtained with . . .
  

   

  

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