HIGHLIGHTS
- who: Anup Gopalakrishna Pillai and Suhita Nadkarni from the Indian Institute of Science Education and Research Pune, Pune, India have published the research work: Amyloid pathology disrupts gliotransmitter release in astrocytes, in the Journal: (JOURNAL)
- what: The authors investigate the roles of two crucial calcium regulating machineries affected by Aβ: plasma-membrane calcium pumps (PMCA) and metabotropic glutamate receptors (mGluRs). The authors propose that the loss of temporal correspondence between calcium events and gliotransmission in astrocytes pathologically alters astrocytic modulation of synaptic transmission in the presence of Aβ accumulation. The authors show that AD-related . . .
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