Amyloid precursor protein and amyloid β peptide in human platelets

HIGHLIGHTS

• who: Daniel M. Skovronsky from the (UNIVERSITY) have published the article: Amyloid Precursor Protein and Amyloid β Peptide in Human Platelets, in the Journal: (JOURNAL) of July/14,/2000
• what: The authors demonstrate that human platelets release A␤ and APP upon their activation by several agonists. The authors provide novel evidence suggesting that APP release from platelets is only partially regulated by COX activation.
• how: The authors examined the regulation of APP cleavage and release from activated platelets and found that cleavage requires protein kinase C (PKC) activity and is regulated by the intracellular . . .
  

   

  

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