An adam17-neutralizing antibody reduces inflammation and mortality while increasing viral burden in a covid-19 mouse model

HIGHLIGHTS

• who: Jodi F. Hedges from the Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, United States, Department of have published the Article: An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model, in the Journal: (JOURNAL)
• what: The authors show for the first time the impact of ADAM17 on both disease outcome and viral burden in K18-hACE2 mice infected with SARS-CoV-2.
• how: For these studies the authors used the highly specific anti-human and antimouse ADAM17 function-blocking mAb . . .
  

   

  

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