An allosteric role for receptor activity-modifying proteins in defining gpcr pharmacology

HIGHLIGHTS

• who: Joseph J Gingell from the School of Biological, University of Auckland, Auckland, New ZealandSciences, Monash University, Parkville, VIC, Australia have published the research: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology, in the Journal: (JOURNAL)
• what: The authors demonstrate that RAMPs allosterically alter the CTR N-terminal domain to enable high-affinity binding to amylin and CGRP peptides. This work provides novel insight into how protein interactions modulate GPCR function. The models were ranked by the Modeller9v8 energy objective function.

SUMMARY

Integral membrane components including other . . .

 



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