An altered glial phenotype in the nl3r451c mouse model of autism

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• who: Samantha M. Matta from the DepartmentThe University have published the article: An altered glial phenotype in the NL3R451C mouse model of autism, in the Journal: Scientific Reports Scientific Reports
• what: Although it is well established that reactive microglia show soma elongation, in the CA1 region of N ­ L3R451C mice the authors report increased microglial soma eccentricity but no change in other parameters relevant to the reactive state such as soma area, cell size or branching patterns. Since the R451C mutation causes a drastic reduction in NL3 protein expression, the authors propose that decreased NL1 . . .
  

   

  

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