An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential*

HIGHLIGHTS

• who: Naoto Yoshizuka from the (UNIVERSITY) have published the research work: An Alternative Transcript Derived from the Trio Locus Encodes a Guanosine Nucleotide Exchange Factor with Mouse Cell-transforming Potential*, in the Journal: (JOURNAL) of August/10,/2004

SUMMARY

Sequence comparison revealed that an alternative RNA_splicing of the Trio gene was involved in the generation of Tgat. Treatment of Tgat-transformed NIH3T3 cells with Y-27632, a pharmacological inhibitor of Rho-associated kinase, abrogated their transforming phenotypes, suggesting the coinvolvement of Rho-GEF activity. Alternative RNA_splicing, resulting in the fusion_protein with the Rho . . .

 



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