An anciently diverged family of rna binding proteins maintain correct splicing of a class of ultra-long exons through cryptic splice site repression

HIGHLIGHTS

• What: The authors propose RBMX family proteins are important for the splicing inclusion of ultra-long exons because these are particularly susceptible to disruption by cryptic splice site selection. The authors show that ectopic expression of RBMXL2 can compensate for lack of RBMX in somatic_cells. As an example, the authors show here that depletion of RBMX protein causes aberrant selection of a high amplitude cryptic splice site within ETAA1 exon 5 which prevents detectable expression of ETAA1 protein, and contributes to genome instability (Bass et_al, 2016 ).
• Who: Chromosomes and colleagues from the Biosciences Institute, Faculty . . .
  

   

  

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