An antagonistic monoclonal anti-plexin-b1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis

HIGHLIGHTS

• who: Melanie Vogler from the (UNIVERSITY) have published the Article: An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis, in the Journal: (JOURNAL) of January/19,/2022
• what: In vitro, the authors show that this antibody inhibits the suppressive effects of Sema4D on human osteoblast differentiation and mineralization. Employing these mice, the authors demonstrate that the anti-Plexin-B1 antibody exhibits beneficial effects in mouse models of postmenopausal osteoporosis and multiple_sclerosis in_vivo. A cross-interaction chromatography analysis was carried out to assess proneness to nonspecific . . .
  

   

  

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