An anti-acvr1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

HIGHLIGHTS

• who: John B. Lees-Shepard et al. from the DepartmentUniversity of, New Haven, Connecticut, USA have published the research: An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice, in the Journal: (JOURNAL)
• what: The authors demonstrate that JAB0505 acts as a weak agonist of ACVR1(R206H) in FAPs and can activate osteogenic signaling, even in the absence of activin A. Treatment of FOP mice with JAB0505 altered the expansion, recruitment, and osteogenic differentiation kinetics of R206H-FAPs and caused a dysregulated immunological response to muscle injury, all of . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.