An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation

HIGHLIGHTS

• What: The authors aimed to develop a highaffinity sortilin-binding affibody-peptide fusion construct, utilizing the fact that PGRN interacts with sortilin through the PGRN Cterminus.
• Who: Mass spectrometry and colleagues from the University of Trieste, Italy have published the paper: An anti-sortilin af body-peptide fusion inhibits sortilin-mediated progranulin degradation, in the Journal: (JOURNAL)

SUMMARY

PGRN is a 593-amino_acid glycoprotein consisting of seven and a half cysteine-rich granulin domains, into which the protein can be cleaved by both intra- and extracellular proteases. Randomized positions are shown . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or E-mail:

If you don't have an account, you can create one here.