HIGHLIGHTS
- What: The authors demonstrate that this integration depends on a plasmid-induced fitness cost, a mobile genetic structure embedding the ARG and a novel antiplasmid system ApsAB actively involved in pOXA-48 destabilization. The authors show that ApsAB targets high and low-copy number plasmids. The authors provide the first evidence of an antiplasmid defense system influencing the evolutionary fate of an antibiotic resistance gene.
- Who: Pengdbamba Dieudonné Zongo from the (UNIVERSITY) have published the article: An antiplasmid system drives antibiotic resistance gene integration in carbapenemase-producing Escherichia coli lineages, in the Journal: (JOURNAL) of . . .
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