An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

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SUMMARY

The authors designated the HMM states as Type 1 LADs (T1-LADs), Type 2 LADs (T2-LADs), and nonLADs in descending order of LB1 occupancy (Fig 1B, C; Additional file 5: Table 2). To validate the HMM results, the authors first confirmed that almost all T1-LAD and a majority of T2-LAD regions are LB1-enriched across atlas cell types (log2 LB1/input > 0 per 20-kb bin; Additional file 2: Fig S3A). Fourth, the authors confirmed the differential LB1 enrichment between T1-LADs and T2-LADs, and relative LB1 depletion in nonLADs . . .

 



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