An autoimmune pleiotropic snp modulates irf5 alternative promoter usage through zbtb3-mediated chromatin looping

HIGHLIGHTS

• who: Zhao Wang from the (UNIVERSITY) have published the paper: An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping, in the Journal: (JOURNAL) of 17/08/2021
• what: Based on the results , the authors propose a model in which an autoimmune disease pleiotropic variant, i.e., rs4728142, directs a short-range chromatin loop between its upstream enhancer and the IRF5-short promoter by affecting the chromatin binding of a putative structural regulator, ZBTB3, which causes aberrant IRF5 activation and autoimmune disease risk (Fig 7e). The authors provide a mechanistic explanation . . .
  

   

  

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