An epilepsy-associated mutation of salt-inducible kinase 1 increases the susceptibility to epileptic seizures and interferes with adrenocorticotropic hormone therapy for infantile spasms in mice

HIGHLIGHTS

• who: Bo Pang and colleagues from the Department of Molecular and Cellular Physiology, Shinshu University School of Medicine, Cutting Edge Research, Shinshu University, Matsumoto, Nagano, Japan have published the research: An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1 Increases the Susceptibility to Epileptic Seizures and Interferes with Adrenocorticotropic Hormone Therapy for Infantile Spasms in Mice, in the Journal: (JOURNAL) of 18/07/2022
• what: The authors investigated the effect of the C-terminal truncated mutation of SIK1 on epilepsy by inducing seizures in SIK1-MT mice.
• how: The authors analyzed male heterozygote . . .
  

   

  

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