An episomal dna vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny

HIGHLIGHTS

  • who: Alicia Roig-Merino from the Vectors, German Cancer Research Center (DKFZ), Heidelberg, Germany Cell Biology, Manchester Metropolitan University have published the research: An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny, in the Journal: (JOURNAL) of January/11,/2022
  • what: The authors demonstrate that these vectors remain episomal and provide robust and sustained transgene expression during self-renewal and targeted differentiation of SCs both in vitro and in vivo through embryogenesis and differentiation into adult tissues without damaging their phenotypic characteristics. For the first time . . .

     

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