An epitope-specific lgi1-autoantibody enhances neuronal excitability by modulating kv1.1 channel

HIGHLIGHTS

• who: Johanna Extru00e9met and collaborators from the Universitu00e9, France Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford University have published the article: An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel, in the Journal: Cells 2022, 2713 of /2022/
• what: The authors show here that two patient-derived mAbs directed against the LRR and EPTP epitopes of LGI1 differentially perturb neuronal excitability in CA3 pyramidal neurons from rat hippocampal organotypic cultures.
• how: LabView (National InstruData were analyzed with Devices ClampFitSan (Axon Data were analyzed with ClampFit (Axon . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.