An evaluation of rna-seq differential analysis methods

HIGHLIGHTS

• who: Dongmei Li and collaborators from the Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester have published the paper: An evaluation of RNA-seq differential analysis methods, in the Journal: PLOS ONE of August/30,/2022
• what: To ensure all compared methods are invariant to library size, the authors evaluate performance under two library size scenarios: equal library size across all samples; RNA-seq differential analysis methods comparison and unequal library size across samples. The RNA-seq count data simulated from the negative binomial distribution could be biased in favor . . .
  

   

  

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