An examination of mediation by dna methylation on birthweight differences induced by assisted reproductive technologies

HIGHLIGHTS

• who: Ellen u00d8. Carlsen from the DNA samples were analyzed at the Institute of Life and Brain Sciences at the University of Bonn in GermanyThe EZ- DNA Methylation-Lightningu2122MagPrep kit (Zymo Research, Irvine, USA) was used for bisulfite conversion. Cord blood DNA methylation of the, newborns was measured using the Illumina Infinium MethylationEPIC array (San Diego, CA, USA) [28]. Details of the quality control pipeline have been described [16]. Briefly, quality control was performed in four batches separately using the RnBeads R package [29]. We excluded, cross-hybridizing probes [30], , probes within three base pairs of SNPs . . .
  

   

  

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