An in-depth comparison of latency-reversing agent combinations in various in vitro and ex vivo hiv-1 latency models identified bryostatin-1+jq1 and ingenol-b+jq1 to potently reactivate viral gene expression

HIGHLIGHTS

• who: Gilles Darcis and collaborators from the University School of Medicine, UNITED STATES, University of Strasbourg, University of Strasbourg, Strasbourg, France have published the paper: An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression, in the Journal: (JOURNAL) of July/30,/2015
• what: The authors showed that combined treatments of PKC agonists (prostratin bryostatin-1 and ing-B) with compounds releasing P-TEFb (JQ1 I-BET I-BET151 and HMBA . . .
  

   

  

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