HIGHLIGHTS
- who: Edward P. Harvey from the (UNIVERSITY) have published the research: An in silico method to assess antibody fragment polyreactivity, in the Journal: (JOURNAL) of 27/04/2022
- what: The authors design a set of experiments using a diverse nau00efve synthetic camelid antibody fragment (nanobody) library to enable machine_learning models to accurately assess polyreactivity from protein sequence (AUC > 0.8). The models provide quantitative scoring metrics that predict the effect of amino_acid substitutions on polyreactivity. The authors provide a companion web-server that offers a straightforward means of predicting polyreactivity and polyreactivity-reducing mutations for . . .
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