HIGHLIGHTS
- who: Dihydrofolate Reductase and colleagues from the Central Laboratory, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana have published the Article: An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase, in the Journal: Journal of Chemistry of 20/05/2022
- what: The authors report herein that biscryptolepine and cryptomisrine (sb class) as well as cryptolepinone cryptoheptine cryptolepine and neocryptolepine (pg class) are capable of inhibiting PfDHFR effectively in pyrimethamine sensitive and resistant cells. This work provides a mechanistic basis for the antiplasmodial action . . .
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