An inhibitor of grp94 inhibits oxldl-induced autophagy and apoptosis in vecs and stabilized atherosclerotic plaques

HIGHLIGHTS

• who: Junying Miao from the China, NHC Key Laboratory of (Shandong, Department of have published the research: An Inhibitor of Grp94 Inhibits OxLDL-Induced Autophagy and Apoptosis in VECs and Stabilized Atherosclerotic Plaques, in the Journal: (JOURNAL)
• what: The authors examined the role of Grp94 in oxLDLinduced autophagy, cell injury in VECs, and atherosclerosis in apolipoprotein E-/- (apoE-/- ) mice.
• how: Showed that the number of LC3 puncta per cell was significantly decreased in the HCP1 treatment group suggesting that HCP1 inhibited autophagy of atherosclerotic vascular endothelium in apoE-/- mice. The results showed that . . .
  

   

  

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