HIGHLIGHTS
SUMMARY
Accordingly, the spatial and temporal patterns of organized immune_responses are complex but, in principle, amenable to rigorous analysis and in-silico experimentation if the external signals and the internal sequences of instructions can be traced and the relations documented. The authors reason that the intricacies of information processing and dynamic adaptation would render comprehensive bottom-up simulation of the immune_response to infections, and rigorous prediction of the outcome, a futile endeavor. Activated autoreactive T_cells that migrate to tissues may act as a new class of innate immunity cells, while ILC subsets functionally resemble certain . . .
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