An internal disulfide locks a misfolded aggregation-prone intermediate in cataract-linked mutants of human γd-crystallin*

HIGHLIGHTS

• who: Eugene Serebryany from the (UNIVERSITY) have published the Article: An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin*, in the Journal: (JOURNAL) of July/12,/2016
• what: The authors investigate such an intermediate-based aggregation mechanism for a lens ␥-crystallin. Unlike the approach introduced by Dima and Thirumalai , the authors did not constrain the distance between proteins' centers of mass; however, both approaches can in principle be used to simulate protein concentration. In fact, the approach yields reasonable results: the strands most often involved in protein . . .
  

   

  

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