An inverse agonist gsk5182 increases protein stability of the orphan nuclear receptor err via inhibition of ubiquitination

HIGHLIGHTS

• who: Soon-Young Na and collaborators from the School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea have published the research: An Inverse Agonist GSK5182 Increases Protein Stability of the Orphan Nuclear Receptor ERR via Inhibition of Ubiquitination, in the Journal: (JOURNAL)
• what: The authors examined the ligand-dependent turnover of ERRu03b3 protein and found that treatment with GSK5182, a specific inverse agonist of ERRu03b3, increased the protein level of ERRu03b3 by suppressing its ubiquitination.
• future: Although ERRu03b3 is ubiquitinated and GSK5182 blocks ubiquitination of ERRu03b3 by inhibiting its . . .
  

   

  

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