An mtorc1-mediated negative feedback loop constrains amino acid-induced flcn-rag activation in renal cells with tsc2 loss

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• who: Kaushal Asrani from the Animal studies Animal protocols were approved by the JHU Animal Care and Use CommitteeThe following strains were used: (1) The Tsc, u00b1 A/J mice, heterozygous for a deletion in exons, were a kind gift from David Kwiatkowski (Harvard University, Boston, USA) and have been previously characterized34, (2) Mice carrying loxP sites flanking exon , and , of Tsc1(Stock Number, Tsc1tm Djk/J) (The Jackson Laboratory). (3) Mice carrying loxP sites flanking exon, and , of Tsc2(Stock Number, Tsc2tm1. Mjgk/J) (The , have published the article: An mTORC1-mediated negative feedback loop constrains . . .
  

   

  

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