An n-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity*

HIGHLIGHTS

• who: Isaac H. Solomon from the (UNIVERSITY) have published the research: An N-terminal Polybasic Domain and Cell Surface Localization Are Required for Mutant Prion Protein Toxicity*, in the Journal: (JOURNAL) of April/22,/2011
• how: The authors therefore decided to test whether PrP expressed in the cytoplasm could exert toxicity measurable in the assays .

SUMMARY

The second assay utilizes whole-cell patch clamping to measure the large spontaneous cationic currents associated with mutant PrP expression. In both the DBCA and patch clamp assay, the largest effects are observed for ⌬105 . . .

 



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