HIGHLIGHTS
- who: Ignacio López from the Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands have published the Article: An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency, in the Journal: (JOURNAL)
- what: The authors show first that transformed embryonic fibroblasts derived from mice haploinsufficient for Ubc9 the essential and unique gene encoding the SUMO E2 conjugating enzyme exhibit enhanced proliferation and transformed phenotypes in vitro and as xenografts ex vivo. Ubc9 haploinsufficiency increases tumorigenesis upon Apc loss in Lgr5+ CBC cells Given the . . .
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