Analysis of complex absorption after multiple dosing: application to the interaction between the p-glycoprotein substrate talinolol and rifampicin

HIGHLIGHTS

  • who: Michael Weiss from the Department of Pharmacology, Martin Luther University Halle-Wittenberg, Halle, Germany have published the article: Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin, in the Journal: (JOURNAL)
  • what: In contrast to the previous analysis that was based on noncompartmental methods , the approach the authors present provides an estimate of the rate of talinolol absorption. A second purpose of this study was demonstrate how multiple dose data can be analyzed with the ADAPT 5 software using a complex absorption model. This . . .

     

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