Analysis of compositional bias in a commercial phage display peptide library by next-generation sequencing

HIGHLIGHTS

  • who: Ane Beth Sloth et al. from the Department of Clinical Physiology and Nuclear Medicine and Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark have published the paper: Analysis of Compositional Bias in a Commercial Phage Display Peptide Library by Next-Generation Sequencing, in the Journal: Viruses 2022, 14, 2402. of /2022/
  • what: Based on these results, the authors discuss how these deviations from randomness are significant for library screening and can negatively impact the selection of genuine binders during cyclic rounds of bio-panning . . .

     

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