Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors

HIGHLIGHTS

• who: . and collaborators from the Regional Community University of Chapecu00f3, Brazil have published the paper: Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors, in the Journal: (JOURNAL)
• what: This approach has several limiting factors, such as the tedious neutrophil isolation and immunoblotting procedures, difficulties in signal quantification, as well as sacrificing the mice. The authors provide a detailed description of this assay, along with validation using antibody competition assays, genetically modified mouse strains and detailed analysis of the effect of the . . .
  

   

  

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