HIGHLIGHTS
SUMMARY
A high level of diversity in NK cell activity and its outcomes may be achieved largely through four different mechanisms: KIR recognition of highly distinct subsets of HLA-I allotypes, combination of KIRs into distinct haplotypes in different individuals, stochasticity of KIR expression on the surface of individual NK cells, and allelic polymorphism of individual KIR genes. To demonstrate the utility of such an automated KIR genotyper, after running KIRCLE on 10,332 TCGA and 49,953 UK biobank exome samples, the authors discovered several novel correlations between KIR allele calls and other molecular . . .
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