Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and ctcf

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  • who: Abrar Aljahani from the MRC Weatherall Institute University of, Nanjing, China have published the Article: Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: A limitation of this studies is that the effects of depletion of cohesin and CTCF on chromatin architecture have been analyzed with genome-wide Chromosome Conformation Capture (3C)25-30,32 and imaging approaches29,38-40 with relatively low resolution. The authors show that cohesin depletion in these regions leads to a subtle . . .

     

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