Ancestral archaea expanded the genetic code with pyrrolysine

HIGHLIGHTS

• who: Li-Tao Guo from the (UNIVERSITY) have published the research work: Ancestral archaea expanded the genetic code with pyrrolysine, in the Journal: (JOURNAL) of May/13,/2022
• what: The authors use biochemical and in_vivo UAG-readthrough assays to characterize the aminoacylation efficiency and substrate spectrum of a u0394PylSn class PylRS from the archaeon Candidatus Methanomethylophilus alvus. The authors show that, compared with the full-length enzyme from Methanosarcina mazei, the Ca. Thermoplasmatota, the analysis shows that u0394PylSn enzymes are also present in archaea of the phylum Euryarchaeota, as well as the TACK group phyla . . .
  

   

  

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