Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

HIGHLIGHTS

• who: Gautier Bailleul from the Gautier Bailleul1, Callum RNicoll2, María Laura Mascotti1, Andrea Mattevi2, *, and Marco W. Fraaije1, * From the Molecular Enzymology Group, University of Groningen, Groningen, the Netherlands have published the paper: Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties, in the Journal: (JOURNAL) of October/15,/2020
• what: The authors aimed at reconstructing the ancestral mammalian FMO1 and FMO4 proteins.

SUMMARY

Intriguingly, AncFMO1 also contains some unique features, including a significantly porous and exposed active_site, and NADPH adopting a new . . .

 



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