HIGHLIGHTS
- who: Nicole Gerwin from the (UNIVERSITY) have published the paper: Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial, in the Journal: CSL (percentage of basal control) of 28/09/2022
- what: The authors show that LNA043 promotes chondrogenesis and cartilage matrix synthesis in_vitro and regenerates hyaline articular cartilage in preclinical OA and cartilage injury models in_vivo. The authors demonstrate that LNA043 is a potent inducer of chondrogenesis in primary hMSC pellet culture, where it dose dependently induces expression of the essential cartilage matrix superficial zone protein PRG4 (lubricin . . .
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