Angptl4 mediates the protective role of pparγ activators in the pathogenesis of preeclampsia

HIGHLIGHTS

• who: Lei Liu from the DepartmentTong University, Shanghai, China have published the paper: ANGPTL4 mediates the protective role of PPARu03b3 activators in the pathogenesis of preeclampsia, in the Journal: (JOURNAL)
• what: The authors show that PPARu03b3 is a prerequisite for the PPARu03b3 agonist-induced expression and secretion of ANGPTL4 in HTR8/SVneo cells, HUVECs and placental explants in a concentration-dependent manner. The authors demonstrate that the PPARu03b3 agonist induces ANGPTL4 expression by regulating the binding of the PPARu03b3/RXRu03b1 heterodimer to its promoter region and enhancing its transcriptional activity.
• how: The results . . .
  

   

  

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