HIGHLIGHTS
- who: Maria Fankhaenel from the Centrosome maturation Loss of proteins required for interphase microtubule organisation , have published the research work: Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis, in the Journal: (JOURNAL) of 27/07/2021
- what: The authors show that disruption of the polarised cortical localisation of the LGN-NuMA-Dynein-Dynactin complex upon ANXA1 depletion leads to elongated and buckled astral microtubules affecting the assembly and orientation of the mitotic spindle, pointing to a role of ANXA1 in the regulation of cortical pulling forces on astral . . .
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