HIGHLIGHTS
SUMMARY
Functional Magnetic Resonance Imaging (fMRI) based on blood oxygenation level-dependent (BOLD) contrast is well-established as a technique to map cortical activity in the brain. Blood f low and volume in WM are only about 25% as large in GM (Rostrup et_al 2000; Helenius et_al 2003) and the energy requirements for WM functions are usually considered low compared with the cortex (Harris and Attwell 2012), so large BOLD effects are not expected. Differences between GM and WM may ref lect the different energy demands of the different cell types within GM and WM . . .
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