HIGHLIGHTS
- who: Sara Marelli and collaborators from the Department of Medicine, University of Cambridge, UK have published the Article: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest, in the Journal: (JOURNAL)
- how: To permit this approach the authors used HeLa cells (HeLas) as a model system.
SUMMARY
The canonical function of HIV-1 Vif is to recruit the cellular restriction factor APOBEC3G for CUL5 E3 ligase and ubiquitin-proteasome-dependent degradation in infected cells, preventing APOBEC3G encapsidation and enhancing virion infectivity (Conticello . . .
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