Antagonism of protein kinase r by large dna viruses

HIGHLIGHTS

  • who: Annabel T. Olson and colleagues from the Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Fairview Ave N Departments of Microbiology, University of Washington, Seattle, WA, USA have published the paper: Antagonism of Protein Kinase R by Large DNA Viruses, in the Journal: Pathogens 2022, 11, 790. of 12/07/2022
  • what: This experiment provided the first indication that HCMV does indeed have one or more genes that can block PKR.

SUMMARY

    The detection of double-stranded RNA (dsRNA) by PKR triggers the shutoff of protein synthesis . . .

     

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