Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging

HIGHLIGHTS

  • who: Montserrat Vega from the (UNIVERSITY) have published the article: Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging, in the Journal: (JOURNAL)
  • what: The shortu2011 or longu2011lived protease mutants display decreased or enhanced respiratory rates, respectively To better understand the possible functions of the mitochondrial proteases in aging, the authors focused on the analysis of the respiratory activity of the deletion mutants. The authors demonstrate that mitophagy is required for lifespan extension in wild-type cells upon glucose depletion and in the long-lived mutants mgr3u0394 and yme1u0394 under glucose-rich . . .

     

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