Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for f508del

HIGHLIGHTS

• What: The aim of this study was to assess the impact of ETI therapy on clinical status and innateimmune cell-derived cytokine signature in the serum as well as peripheral blood mononuclear cells (PBMCs) harvested from adults with CF (awCF) heterozygous for F508del. This study evaluated the clinical and anti-inflammatory effect of ETI in awCF who were modulator naïve and heterozygous for F508del. While the study was not designed or powered to investigate the Anti-inflammatory effects of triple CFTR modulator therapy in cystic fibrosis clinical efficacy of ETI treatment, the authors were reassured by . . .
  

   

  

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