Anti-pd-1 immune-related adverse events are associated with high therapeutic antibody fixation on t cells

HIGHLIGHTS

• who: Marianne Gazzano and collaborators from the San Martino (IRCCS), Italy have published the article: Anti-PD-1 immune-related adverse events are associated with high therapeutic antibody fixation on T cells, in the Journal: (JOURNAL)
• what: The authors report features with AUC > 0.65 as discriminatory. The authors propose a CD4 mediated mechanism for the pulmonary toxicities the authors studied.
• future: Analysis is required to determine if this difference is linked to irAE occurrence.

SUMMARY

ICI can also alter T_cell-B cell interactions resulting in pathogenic autoantibody production . . .

 



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