HIGHLIGHTS
- Who: Lekshmi R. Nath and collaborators from the Amrita Vishwa Vidyapeetham, India Jagiellonian University Medical College, Poland have published the research: Anti-tumor effect and hepatotoxicity mechanisms of psoralen, in the Journal: (JOURNAL)
- How: The results showed that PSO significantly promoted the expression of GRP78 and GRP94 inducing the unfolded protein response and leading to liver cancer cell apoptosis.
- Future: Research on its precise mechanisms target actions and clinical applications is needed.
SUMMARY
UPR protects cells from stress and helps them re-establish homeostasis, while prolonged endoplasmic_reticulum stress activates . . .
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