Antiandrogenic effects of a polyphenol in carex kobomugi through inhibition of androgen synthetic pathway and downregulation of androgen receptor in prostate cancer cell lines

HIGHLIGHTS

  • who: Yudai Kudo and collaborators from the Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu, Japan have published the paper: Antiandrogenic Effects of a Polyphenol in Carex kobomugi through Inhibition of Androgen Synthetic Pathway and Downregulation of Androgen Receptor in Prostate Cancer Cell Lines, in the Journal: (JOURNAL)
  • what: This study was conducted to evaluate the pathophysiological roles of DHRS11 in PC using three LNCaP C4-2 and 22Rv1 cell DHRS11 silencing and inhibition resulted in suppression of the androgen-induced expression of AR downstream genes and decreases in the expression of nuclear AR and the . . .

     

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